Nitric oxide (N-O) is crucial for optimum health. It helps to relax your blood vessels and improve blood circulation, thus may support healthy blood pressure and increasing nutrient and oxygen delivery to every system, organ, and tissue in the body.

In the field of medical research, N-O is being researched for its many benefits, including those that may help the body to:

  • Support healthy blood pressure levels

  • Support cardiovascular and heart health

  • Promote increased circulation throughout the body

  • Support normal, healthy circulation

  • Support healthy arterial function

  • Promote artery dilation for healthy blood flow

Nitric oxide and endothelial health are closely intertwined. N-O helps keep the endothelium healthy; a healthy endothelium helps produce nitric oxide. Maintaining the proper functioning of this cycle is important for those who want to enjoy vibrant health at every age.

Addressing the Problem
Most N-O products available to healthcare practitioners today do not and cannotwork effectively. That’s because inherent inefficiencies in human metabolism often limit product efficacy.

Many N-O-based products contain L-arginine or L-citrulline as their active ingredient. Simply giving more L-arginine to a patient with dysfunctional NOS enzymes will likely not provide much benefit since the enzyme that converts L-arginine to N-O is the underlying problem. It’s not possible to fuel a system that is broken.

N-O activity is what directs the repair of the endothelium and recoupling of the NOS enzymes necessary for restoring N-O production. Thus, restoration requires a source of N-O. That’s where Neo40® Pro comes in. It is the only clinically demonstrated solution that may restore nitric oxide levels through breakthrough technology that delivers immediate N-O. With continued use over time, Neo40® Pro can help restore endothelial function so that the body can make its own N-O once again.

Why do N-O levels fall?
As the body ages, nitric oxide production declines. Studies show that by age 40 the body makes about half or less Nitric Oxide than at age 20. By the age of 40, most men produce only about 50% of the N-O in the body as they did in their teens and twenties.

Women fare worse. By age 50, their available N-O levels are typically only about 35% of women in their twenties. It takes a conscious and concerted effort to keep N-O levels up.

Exercise and foods that are a source of dietary nitrates are more important than ever, but they still may not be enough. N-O supplementation can be a wise choice to help you support cardiovascular health and enjoy more all-around energy.

How do you know if you need N-O? – by Nathan S. Bryan, Ph.D.
Although nitric oxide or N-O is considered one of the most important molecules produced in the human body with over 140,000 published papers in the scientific literature, still physicians do not always recognize which of their patients may be suitable for N-O supplementation.

Moreover, patients and consumers understand N-O even less and don’t fully understand if or why they should take N-O based products or supplements. Much of this stems from the fact that there are no labs or common tests that can determine N-O production or N-O status in patients. You can test your Vitamin D, Vitamin B or omega 3 fatty acid levels and if you are low, then it is easy to supplement with these products to restore normal levels. This concept is exactly the same for N-O. People become low in N-O and loss of N-O production is considered one of the earliest events in the onset and progression of most if not all age related diseases [1-5], including cardiovascular disease, the #1 killer of men and women worldwide.


So how do you know if you need a safe and effective N-O product? Functional changes in the blood vessels occurs years, sometimes decades, before the structural changes begin to occur [5]. Therefore getting functional test that determines endothelial function is critical for determining N-O production capacity and function before the onset and progression of symptoms or disease.

There are also well validated biomarkers that appear in blood that mirror the progressive loss of N-O production. The first phase of insufficient N-O production is an increase in inflammation. The acute phase inflammatory marker hsCRP begins to increase. Subjects will also experience protein in the urine or microalbuminuria.  The presence of protein in the urine is a very early marker of cardiovascular dysfunction.

In later stages, once N-O production is decreased by greater than 50%, there is heightened oxidative stress. This can be picked up by increase in myeloperoxidase (MPO) activity, oxidized lipoproteins (Lp-PLA2), increased excretion of F2 isoprostanes in the urine. If any of these biomarkers are increased or elevated, then you can be certain your body is not producing sufficient N-O. As a result, since you are deficient in N-O, then it is prudent to supplement N-O and take steps to improve your body’s own ability to make N-O.

In this time of changing health care and the practice of medicine, it is time to be proactive in the control of our health instead of being reactive once you get sick or begin to show symptoms of disease. This is where N-O supplementation can have the most profound impact on public health.


The published literature reveals that age is the number one cause of loss of nitric oxide production [6-9]. This loss of endothelial function can be accelerated or decelerated by our diet and lifestyle. Taking measures to prevent the age related decline in N-O production will ensure that your blood vessels remain healthy and responsive. The old saying “an apple a day will keep the doctor away” may be even more true with N-O. Daily moderate physical exercise and a diet enriched with green leafy vegetables is a great way to keep your N-O levels up. For those that do not want to change diet or exercise, there are N-O supplements and functional foods available to those. Whatever your choice, it is paramount that everyone keep their N-O levels optimal for great health and well-being.